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Platelet transfusion

From Surgopaedia

Indications

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  • Platelet cut-off of 50 is reasonable for invasive procedures - give 1 unit and assess response

Components available

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  • Apheresis: 280 x10^9 in 210mL
    • Collected from a single donor by using an apheresis machine with an integrated leucoreduction system, then returns the remaining blood back to the donor
    • Have higher residual plasma content
    • Much more costly
    • Indications:
      • Requirement for HLA compatible and/or HPA matched platelets
      • Patients who require IgA deficient platelets
      • Neonates/small children whose platelet dose requirement can be met by a split apheresis component, to avoid wastage of part of a pooled bag
  • Pooled: 290 x 10^9 in 370mL
    • Produced via the Buffy Coat method - pooled from separate ABO-identical whole blood donations using a platelet additive solution, then centrifuged, filtered and rested to produce a leucodepleted pooled platelet unit
  • Paed: 75 x 10^9 in 55mL

Administration

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  • Expected rise in a 70kg stable adult is 20-40 x 10^9/L
  • Give over 30 mins
  • In an adult, generally give 1 unit pooled (or apheresis if they have a specific indication)