Hypoglycaemia
Hypoglycaemia
- Aetiology:
- Accelerated insulin absorption
- Exercise
- Hot environmental conditions
- Unfavourable factors relating to insulin administration
- Too early
- Too much
- Inadequate food intake
- Alcohol consumption (inhibits hepatic gluconeogenesis)
- Loss of counter-regulatory hormones
- Addison's disease
- Hypothyroidism
- Hypopituitarism
- Blunted glucagon secretion (as in long-standing T1DM)
- Intestinal malabsorption
- Renal failure (impaired insulin clearance)
- Accelerated insulin absorption
- Natural history:
- ~3.8 - adrenaline and glucagon secretion increases
- ~3 - onset of hypoglycaemic symptoms
- ~2.8 - neuroglycopaenia and cognitive impairment
- <1 - coma