FFP transfusion

Indications

• Deficiency of clotting factors with bleeding or risk of bleeding, where specific therapy (e.g. clotting factor concentrates) is not appropriate or available
  • Useful when the specific clotting deficiency can't be treated with the exact product
• Prevention of dilutional coagulopathy in the setting of MTP
• DIC
• Plasma exchange (TTP)
• Reversal of warfarin anticoagulation

Component

• FFP - whole blood or apheresis unit - 275mL
• Paed unit - 70mL

Administration

• Adults, paeds and neonates: 10-15mL/kg, rounded to nearest unit (in most cases give 15mL/kg)
• Give over 30-120 mins based on volume tolerance

Outcomes

• INR changes may not correlate with clinical effect
• The effect can be transient