Transplant background
Types of transplant
[edit | edit source]- Isografts - organ from genetically identical twin
- Allograft - organ from genetically dissimilar individual
- Xenograft - organ from another species
Preparation of living donors for transplant:
[edit | edit source]- Assess current function and anatomy of organ in question
- E.g. for kidney, look at eGFR, vasculature
- Assess risk to donor of donation
- Ensure no risk of transmitting pathology to recipient
- Malignancy
- Infections
- Check immune compatibility
- Psychological assessment and motivation
- Give informed consent
Methods of improving graft survival
[edit | edit source]- Live donor transplant
- Preservation - cooling, solutions
- Matching HLA class I and II antigens (but not done for livers)
- Risk factors of recipient
- Recipient immune suppression