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Anterior resection

From Surgopaedia

Indications:

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    • Rectal/sigmoid cancer
      • Margins: 5cm proximally, 1-2cm distally (aim 5cm distally if upper rectal), 1mm circumferentially
      • Aim for 12 or more lymph nodes in specimen
    • Recurrent diverticular disease
    • Stricture

Goals

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    • Oncologic:
      • Histologically negative margins (aim for 2cm gross longitudinal margin for rectal cancers)
      • CME/TME
        • See 'rectal cancer' topic for TME
        • Complete Mesorectal Excision refers to resection of colon and mesocolon within its peritoneal envelope, with implied high arterial ligation
      • Adequate lymphadenectomy (12 lymph nodes)
      • High ligation of IMA (to enable adequate lymphadenectomy)
    • Consider low and high ligation of IMV, to allow enough length for a tension-free anastomosis
    • Avoid injury to pelvic autonomic nerve
    • Preserve anorectal function

Prep:

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    • Ensure distance above AV has been confirmed pre-op
      • >10cm HAR
      • 6-9cm LAR
      • <6cm ULAR
    • Mechanical bowel prep and PO antibiotics the day before are probably beneficial - especially mech prep if might need to do colonoscopy on-table. However many colorectal surgeons don't do it. Does making the stool more liquid also make it easier for it to leak out?
    • On-table cefazolin + metronidazole
    • ?prophylactic ureteral stenting in high-risk patients - obese, bulky tumours, reoperations, radiotherapy, etc
    • VTE prophylaxis - controversial, probably doesn't need to happen on-table

Set-up:

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    • GA, prep (probably don't need to prep perineum), drape, lithotomy with both arms tucked or left arm out (surgeon at right, assistant at left initially), IV Abx, TEDs + SCDs
    • Harmonic/Ligasure
    • IDC
    • Stand on patient's right - be aware of cables near patient's right neck e.g. Bair hugger as they can be leant on by assistant
    • Open: long midline incision (around left of umbilicus to give better access to splenic flexure)
    • Lap: 10mm infra-umbilical, 12mm RLQ, 5mm RUQ, 5mm LUQ

Technique:

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    • Check liver/peritoneum for mets
    • Push omentum above liver. Get bowel out of the way - head down, left side up, fold leaflets away like a book, consider extra fan retractor.
    • Adhesiolysis and mobilisation of sigmoid colon
      • Lateral to medial when you will be resecting right along the colonic margin (benign)
        • Incise along white line of Toldt, working up towards splenic flexure
        • Careful attention to correct plane, first medial to peritoneal sidewall, then anterior to anterior renal fascia (Gerota's)
      • Medial to lateral when you will be formally ligating IMA (cancer), and provided you can get the bowel out of the way
        • Tent up sigmoid and identify IMA/IMV, at the sacral promontory, where there is an impression at the CME margin. Iliacs will be just behind.
        • Identify ureter prior to ligating IMA
        • Dissect IMA out to 1cm distal from origin and LigaSure/staple/hemolok/suture ligate (LigaSure x3 is a good option, especially in young patients)
        • Ligate IMV adjacently (this is low ligation IMV)
        • Continue medial to lateral - tent up doona over head and make a window, looking for ureter. Stay directly underneath IMA to avoid digging under ureter.
    • Ureter and left gonadal vessel identification, if not already seen
    • Mobilisation of colon and upper rectum
      • Incise the retroperitoneal fascia medial to ureter, and work across in the presacral space, in a plane anterior to the left presacral hypogastric nerve.
      • Carry dissection across sigmoid mesentery as far as necessary
    • Further mobilisation towards splenic flexure if required
      • Need enough length to easily bring it down to pelvis
      • Divide phrenocolic ligament, avoiding spleen and tail of pancreas
      • Divide adhesions between omentum and colon proximally to mid-transverse colon, entering the lesser sac
      • Divide IMV high (next to DJ ligament) if more length is required
    • Dissection and division of rectum
      • Select a point for division (good blood supply, free of diverticulae). Clear the mesenteric border for approx. 2cm, but stay fairly close posteriorly, to avoid damaging nerves.
      • TME to 2-5cm below the point of division (if malignancy) - lift sigmoid vertically with Ray-Tec posteriorly, divide the peritoneum on either side. Dissect posteriorly between pre-sacral fascia and mesorectum, preserving the pre-sacral nerves. Dissect anteriorly between seminal vesicles/vagina and rectum to expose the rectovesical fascia. Continue dissecting in avascular plane between mesorectum and pelvic sidewall.
      • Fire TA linear stapler (green 60) across this point
    • Colon extraction and division - limited Pfannenstiel or Lanz incision
      • If converting to open with dissection still to be done, do lower midline
    • Anastomosis - EEA/sutured
      • See topics under 'anastomosis' and 'stapling'
      • Check marginal artery for pulsatile flow at anastomosis site - if not present, need to go proximal
      • Covering ileostomy if concerns
      • Leak test
        • Suturing over defect
        • Defunctioning stoma
        • Reconstruction of anastomosis
    • Consider loop ileostomy and drain
      • For LAR, reduce risk of leak from 28% to 10% with a covering loop ileostomy
    • Closure

Post-op instructions:

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    • ERAS - clear fluids straight away and cease IVF same day. Upgrade to full diet the next day if tolerating
    • Avoid NGT, IDC out ASAP
    • Minimise opioids
    • Early mobilisation
    • Consider extended duration enoxaparin for cancer operations

Complications:

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    • Leak
      • See separate topic
    • Necrosis of transposed colon
      • Aggressive treatment - creation of terminal stoma
    • Low anterior resection syndrome
      • Consequence rather than a true complication (may be present in 80% after LAR)
      • Risk factors
        • TME
        • Colon-anal anastomosis
        • Neoadjuvant chemoradiation
        • Previous leak
      • Presentation
        • Syndrome - frequency, multiple fragmented bowel movements, sensation of incomplete emptying, incontinence, constipation, and diarrhoea
        • Most of the symptoms improve 1 year or more after the resection, but most do have some degree of persisting dysfunction
      • Pathophysiology
        • Multifactorial
        • Injury to internal sphincter
        • Loss of sensitivity of the anorectal mucosa
        • Loss or impairment of the rectoanal-inhibitory reflex
        • Reduction of the capacity of the rectal reservoir
        • Loss of compliance of the transposed colon
      • Treatment
        • Empirical
        • Diet control
        • Loperamide and fibre products
        • Physical therapy including biofeedback
        • Trans-anal irrigation
        • Construction of end stoma can sometimes be necessary as a definitive treatment
    • Autonomic nerve injury
      • Sites of injury
        • IMA ligation - pre-aortic sympathetic plexus
        • Sigmoid mobilisation - superior hypogastric plexus
        • TME laterally - inferior hypogastric plexus
        • TME anteriorly - terminal branches pelvic autonomic nerves
      • Injury:
        • Bowel dysfunction - urgency, frequency, incontinence)
        • Sexual dysfunction - erectile dysfunction, retrograde ejaculation
        • Urinary problems - difficulty voiding, incontinence
    • Reduced fertility
      • 73% of women with childhood total proctocolectomy/IPAA who desired to become pregnant were able to conceive
      • Probably largely related to adhesions, rather than autonomic damage
    • Ureteric injury
      • Key factors site of injury, presence of tension, viability of cut ends
      • Surgical pause
      • Intra-op urology consult
      • Options to temporise if no urologist available:
        • Drain adjacent to injury (perfectly acceptable)
        • Nephrostomy
        • Externalised stent
        • Ureter externalised and sutured to skin
      • Distal injuries (below SIJ):
        • Primary repair if >4cm proximal to VUJ
        • Ureteric reimplantation +/- adjuncts such as psoas hitch
      • Middle injuries (overlying SIJ):
        • Primary repair if possible without tension
        • Reimplantation via Boari flap
        • Reimplant to contralateral ureter - rare
      • Proximal injuries:
        • Primary repair if possible
        • Ileal or appendiceal interposition graft
        • Auto transplantation
        • Nephrectomy
      • Techniques:
        • Primary repair
          • Mobilise
          • Debride ends
          • Spatulate
          • Interrupted absorbable monofilament
          • Stent across join in most cases