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== Metoclopramide == * Improves gastric emptying by enhancing gastric antral contractions and decreasing postprandial fundus relaxation * Doesn't have any impact on colon * First-line for gastroparesis * Side effects: ** Anxiety ** Restlessness ** Depression ** Hyperprolactinaemia ** Prolonged QT ** EPS including dystonia == Domperidone == * Likely efficacy for gastroparesis is similar to metoclopramide * Increased risk of arrhythmias == Erythromycin == * Third-line for gastroparesis after metoclopramide and domperidone * Motilin agonist * Induces high-amplitude gastric propulsive contractions that increase gastric emptying, and stimulates fundic contractility * Can be given as oral (40-250mg TDS) or IV (stronger effect) * Should only give for 4 weeks at a time due to tolerance/tachyphylaxis == Cisapride == * Stimulates antral and duodenal motility and accelerates gastric emptying of solids and liquids * Only used for patients that have failed all others, due to risk of cardiac arrhythmias [[Category:Pharmacology]] [[Category:UGIS]]
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