Editing Sepsis/SIRS (section)

=== '''''Old criteria:''''' ===

** '''''SIRS''''' ''(no longer recommended for clinical use by sepsis 3 - think of it as an appropriate, regulated non-specific response to infection)''':'''''
*** ''Two or more of:''
**** ''Temp >38 or <36''
**** ''HR >90''
**** ''RR>20''
**** ''WCC >12 or <4''
**** ''Acutely altered mental state''
**** ''BGL > 6.6 in absence of diabetes''
** '''''Sepsis = SIRS + documented source of infection'''''
*** ''Alternative definition from CCrISP is of 'a life-threatening organ dysfunction caused by a dysregulated host response to infection'''
** '''''Severe sepsis = SIRS + altered organ perfusion''''' ''(no longer a clinically useful definition according to CCrISP)''
*** ''CVS (lactate > 1.2)''
*** ''Pa02/Fi02 < 30 or Pa02 < 9.3kPa''
*** ''Urine output < 120ml over 4 hours''
*** ''GCS < 15 acutely''
** '''''Septic shock:''''' ''infection plus''
*** ''Definition 1:''
**** ''Vasopressors to maintain MAP >65, '''and'''''
**** ''Lactate >2''
*** ''Associated with 40% mortality''