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== '''Treatment''' == * '''ECOG 3 or 4: straight to best supportive care''' * Resectable (stage I or II): either upfront surgery or neoadjuvant treatment with FOLFIRINOX + CRT then surgery * Borderline resectable - Neoadjuvant CTX +/- RTX for 2/12, then re-image, and assuming no progression, can be resected, then adjuvant therapy ** Some centres may do a second stage of neoadjuvant therapy prior to OT * Locally advanced unresectable - CTX, it may become resectable later, but this is rare. Consider RTx if persistent disease after CTx (although RCT 2016 'LAP07' suggested doesn't help) ** Irreversible electroporation is an area of study * Unresectable (stage IV) - CTX
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