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Helicobacter pylori
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== '''Eradication therapy''' == * First-line: HP7 for 14 days ** Esomeprazole 20mg orally bd ** Amoxicillin 1g orally bd ** Clarithromycin 500mg orally bd * Allergic to penicillins: for 14 days ** PPI BD ** Metronidazole 400mg BD ** Clarithromycin 500mg BD * Second-line ** Quinolone therapy (10 days) - efficacy >85% - preferred second-line in Australia *** PPI BD *** Amoxicillin 1g BD *** Levofloxacin 250mg BD or moxifloxacin 400mg BD ** Bismuth (7-14 days) *** PPI BD *** Colloidal bismuth subcitrate 120mg QID on an empty stomach *** Tetracycline 500mg QID on an empty stomach *** Metronidazole 400mg TDS with food * Third-line ** Rifabutin-based triple therapy *** PPI BD *** Amoxicillin 1g BD *** Rifabutin 150mg BD * ''Basically, amoxicillin and PPI are always given, but the other drug is clarithromycin -> moxifloxacin -> rifabutin'' * ''If allergic to penicillin, just swap out the amoxicillin for metronidazole''
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