Editing GORD (section)

== '''Pathophysiology''' ==

* GORD occurs when     intra-gastric pressure is greater than high-pressure zone of the distal     oesophagus
** Resting LOS pressure is too      low (frequently associated with hiatal hernia - displacement of GOJ into      the posterior mediastinum)
** Inappropriate relaxation of      LOS in the absence of peristaltic contraction of the oesophagus (can      occur in normal anatomic position)
* Some degree of GORD is     physiological, occurring in the setting of a normal LOS. Allows us to     rapidly evacuate swallowed air from the stomach, that would otherwise     cause bloating and flatulence.
** Pathological GORD occurs      with greater oesophageal acid exposure, worse symptoms, and the presence      of mucosal damage of the oesophagus
* Hiatal hernias often     associated with GORD - abnormal anatomy compromises the LOS
** See separate topic