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Pancreatic cancer
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== '''Presentation''' == * Obstructive jaundice - defining feature of PDAC in the periampullary region * Weight loss - seen in >50% * Abdominal pain - typically epigastric, radiating through to back * HOP tumours present with jaundice, while tumours in body and tail cause pain and weight loss * New-onset diabetes in an elderly patient, especially with weight loss and pain, can be an early presenting symptom of pancreatic cancer * Examination findings unremarkable. 30% have a distended GB. Virchow's node may be palpable, or Sister Mary Joseph nodule. Peritoneal tumour involvement may be palpable on Blumer shelf. *
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