Editing Nipple discharge (section)

=== Lactational ===
{| class="wikitable"
|'''Medication class'''
|'''Frequency of prolactin elevation*'''
|'''Mechanism'''
|-
|'''Antipsychotics, first generation'''
|
|
|-
|Chlorpromazine
|Moderate
|Dopamine D2 receptor blockade within hypothalamic tuberoinfundibular system.
|-
|Fluphenazine
|High
|
|-
|Haloperidol
|High
|
|-
|Loxapine
|Moderate
|
|-
|Perphenazine
|Moderate
|
|-
|Pimozide
|Moderate
|
|-
|Thiothixene
|Moderate
|
|-
|Trifluoperazine
|Moderate
|
|-
|'''Antipsychotics, second generation'''
|
|
|-
|Aripiprazole
|None or low
|Dopamine D2 receptor blockade.
|-
|Asenapine
|Moderate
|
|-
|Clozapine
|None or low
|
|-
|Iloperidone
|None or low
|
|-
|Lurasidone
|None or low
|
|-
|Olanzapine
|Low
|
|-
|Paliperidone
|High
|
|-
|Quetiapine
|None or low
|
|-
|Risperidone
|High
|
|-
|Ziprasidone
|Low
|
|-
|'''Antidepressants, cyclic'''
|
|
|-
|Amitriptyline
|Low
|Not well understood. Possibly by GABA stimulation and indirect modulation of prolactin release by serotonin.
|-
|Desipramine
|Low
|
|-
|Clomipramine
|High
|
|-
|Nortriptyline
|None
|
|-
|'''Antidepressants, SSRI'''
|
|
|-
|Citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline
|None or low (rare reports)
|Same as for cyclic antidepressants.
|-
|'''Antidepressants, other'''
|
|
|-
|Bupropion, venlafaxine, mirtazapine, nefazodone, trazodone
|None
|Not applicable.
|-
|'''Antiemetic and gastrointestinal'''
|
|
|-
|Metoclopramide
|High
|Dopamine D2 receptor blockade.
|-
|Domperidone (not available in United States)
|High
|
|-
|Prochlorperazine
|Low
|
|-
|'''Antihypertensives'''
|
|
|-
|Verapamil
|Low
|Not well understood. Specific to verapamil. May involve calcium influx inhibition within tuberoinfundibular dopaminergic neurons.
|-
|Methyldopa
|Moderate
|Decreased conversion of L-dopa to dopamine; suppression of dopamine synthesis.
|-
|Most other antihypertensives (including other calcium channel blockers)
|None
|Not applicable.
|-
|'''Opioid analgesics'''
|
|
|-
|Methadone, morphine, others
|Transient increase for several hours following dose
|Potentially an indirect effect of mu opiate receptor activation.
|}