Editing Gallbladder cancer (section)

== '''Presentation''' ==

* Frequently asymptomatic, since most cancers form in body/neck
* Symptoms are a good prognostic indicator, since it means they present earlier
** Can present with symptoms of acute or chronic cholecystitis
** Constitutional symptoms
* Specific situations:

** '''Pre-operative workup for biliary symptoms'''

** Cancer can cause similar symptoms to biliary colic

** '''Incidental imaging finding'''

** Any GB mass, or polyp > 1cm, or presence of porcelain GB, should raise suspicion
** DDx of GB mass
*** Benign:
**** Cholesterolosis
**** Cholesterol polyps
**** Adenomyomatosis
**** Intracholecystic papillary-tubular neoplasms (ICPN/inflammatory polyps and adenomas)
*** Malignant
**** GB cancer
**** Mets

** '''Intra-operatively'''

** Do not need to immediately convert to open - best to abort operation and refer to HPB surgeon

** '''Post-operatively on histopathology'''
*** '''Early GB cancer may be difficult to differentiate from chronic cholecystitis'''