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== Staging == * See 'pancreatic NETs' topic Staging duodenal/ampulla of Vater NENs {| class="wikitable" |'''Primary tumor (T)''' | | | |- |'''T category''' |'''T criteria''' | | |- |TX |Primary tumor cannot be assessed | | |- |T1 |Tumor invades the mucosa or submucosa only and is β€1 cm (duodenal tumors). Tumor β€1 cm and confined within the sphincter of Oddi (ampullary tumors). | | |- |T2 |Tumor invades the muscularis propria or is >1 cm (duodenal). Tumor invades through sphincter into duodenal submucosa or muscularis propria, or is >1 cm (ampullary). | | |- |T3 |Tumor invades the pancreas or peripancreatic adipose tissue | | |- |T4 |Tumor invades the visceral peritoneum (serosa) or other organs | | |- |''NOTE:'' Multiple tumors should be designated as such (and the largest tumor should be used to assign the T category): * If the number of tumors is known, use T(#); eg, pT3(4) N0 M0. * If the number of tumors is unavailable or too numerous, use the m suffix, T(m); eg, pT3(m) N0 M0. | | | |- |'''Regional lymph nodes (N)''' | | | |- |'''N category''' |'''N criteria''' | | |- |NX |Regional lymph nodes cannot be assessed | | |- |N0 |No regional lymph node involvement | | |- |N1 |Regional lymph node involvement | | |- |'''Distant metastasis (M)''' | | | |- |'''M category''' |'''M criteria''' | | |- |M0 |No distant metastasis | | |- |M1 |Distant metastases | | |- |M1a |Metastasis confined to liver | | |- |M1b |Metastases in at least one extrahepatic site (eg, lung, ovary, nonregional lymph node, peritoneum, bone) | | |- |M1c |Both hepatic and extrahepatic metastases | | |- |'''Prognostic stage groups''' | | | |- |'''When T is...''' |'''And N is...''' |'''And M is...''' |'''Then the stage group is...''' |- |T1 |N0 |M0 |I |- |T2 |N0 |M0 |II |- |T3 |N0 |M0 |II |- |T4 |N0 |M0 |III |- |Any T |N1 |M0 |III |- |Any T |Any N |M1 |IV |}
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