Editing Breast cancer (section)

== Prognosis ==

* Stage I: 5 year 98.7% survival rate
* Overall 5 year survival rate of 90%
* Most patients with metastatic disease die of breast cancer
* Local recurrence
** Older women with hormone receptor positive cancer: 0.4% per year
** Younger women with triple negative: 1% per year


'''Risk profile and associated survival outcomes, MD Anderson validation of biomarkers in TNM 8th edition staging'''
{| class="wikitable"
| 
|'''Five-year DSS'''

'''(%)'''
|'''Univariate analysis'''
|
|'''Multivariate analysis 2'''
|
|'''Assigned points'''
|-
|
|
|'''HR'''
|'''''p'''''
|'''HR'''
|'''''p'''''
|
|-
|'''Pathological stage'''
|
|
|
|
|
|
|-
|I
|99.1
|Referent
|
|Referent
|
|0
|-
|IIA
|98.0
|2.8
|0.002
|2.3
|0.01
|1
|-
|IIB
|95.6
|4.8
|<0.0001
|4.0
|<0.0001
|2
|-
|IIIA
|95.4
|6.8
|<0.0001
|7.2
|<0.0001
|3
|-
|IIIC
|79.5
|26.6
|<0.0001
|19.9
|<0.0001
|4
|-
|'''Nuclear grade'''
|
|
|
|
|
|
|-
|I
|99.8
|Referent
|
|Referent
|
|0
|-
|II
|98.9
|5.0
|0.1
|4.0
|0.2
|0
|-
|III
|95.3
|25.0
|0.001
|13.1
|0.01
|1
|-
|'''ER status'''
|
|
|
|
|
|
|-
|Positive
|98.8
|Referent
|
|Referent
|
|0
|-
|Negative
|92.9
|4.9
|<0.0001
|2.5
|0.001
|1
|-
|'''PR status'''
|
|
|
|
|
|
|-
|Positive
|98.8
|Referent
|
|Referent
|
|
|-
|Negative
|95.2
|4.0
|<0.0001
|
|NS
|
|-
|'''HER2 status'''
|
|
|
|
|
|
|-
|Positive
|97.5
|Referent
|
|Referent
|
|0
|-
|Negative
|98.0
|0.8
|0.5
|2.2
|0.04
|1
|-
|'''Factor'''
|'''0 points'''
|
|
|'''1 point'''
|
|
|-
|Grade
|Grade 1/2
|
|
|Grade 3
|
|
|-
|ER status
|ER positive
|
|
|ER negative
|
|
|-
|HER2 status
|HER2 positive
|
|
|HER2 negative
|
|
|-
|'''Stage'''
|'''Risk profile'''
|'''N'''
|'''Five-year DSS'''

'''(%)'''
|'''95% CI'''
|'''Five-year OS'''

'''(%)'''
|'''95% CI'''
|-
|I (IA and IB)
|0
|36
|100
|
|97
|80.4-99.6
|-
|
|1
|1173
|99.4
|98.7-99.7
|96.7
|95.4-97
|-
|
|2
|274
|98.8
|96.4-99.6
|94.6
|91-96.8
|-
|
|3
|119
|96.6
|91.1-98.7
|93.8
|87.5-97
|-
|IIA
|0
|31
|100
|
|96.8
|79.2-99.5
|-
|
|1
|634
|99.4
|97.5-99.8
|97.1
|94.7-98.4
|-
|
|2
|236
|97.5
|93.2-99.1
|94.1
|88.7-97
|-
|
|3
|98
|91
|81.8-95.7
|88.2
|78.5-93.8
|-
|IIB
|0
|11
|100
|
|100
|
|-
|
|1
|309
|96.9
|92.6-98.8
|94.6
|89.6-97.2
|-
|
|2
|107
|92.9
|83.6-97.1
|89.3
|80.1-94.4
|-
|
|3
|40
|91.5
|75.6-97.2
|91.5
|75.6-97.2
|-
|IIIA
|0
|3
|100
|
|100
|
|-
|
|1
|134
|98.3
|88.2-99.8
|91.5
|82.6-96
|-
|
|2
|50
|92.2
|77.2-97.5
|90.3
|75.7-96.3
|-
|
|3
|7
|68.6
|21.3-91.2
|68.6
|21.3-91.2
|-
|IIIC
|0
|0
|
|
|
|
|-
|
|1
|39
|92.2
|72.1-98.0
|84.4
|63.7-93.9
|-
|
|2
|16
|80.8
|51.4-93.4
|80.8
|51.4-93.4
|-
|
|3
|10
|33.3
|6.3-64.6
|33.3
|6.3-64.6
|}











[[Category:Breast]]