Jump to content
Main menu
Main menu
move to sidebar
hide
Navigation
Main page
Recent changes
Random page
Help about MediaWiki
Special pages
Surgopaedia
Search
Search
Appearance
Create account
Log in
Personal tools
Create account
Log in
Pages for logged out editors
learn more
Contributions
Talk
Editing
Pancreatic cancer
(section)
Page
Discussion
English
Read
Edit
Edit source
View history
Tools
Tools
move to sidebar
hide
Actions
Read
Edit
Edit source
View history
General
What links here
Related changes
Page information
Appearance
move to sidebar
hide
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
== '''Pathophysiology''' == * Refers to primary cancers of the ductal epithelium, as well as cancers arising from MCN and IPMN * Progression from pancreatic intra-epithelial neoplasia (PanIN) to invasive cancer ** KRAS2 oncogene is activated in >95% and is thought to be the initiating event in tumourigenesis ** CDKN2A, p53 and SMAD4 are tumour suppressor genes that may also play critical roles ** PanIN: progressive abnormality of the ductal epithelium *** PanIN-1A: columnar, mucin-producing ductal epithelium that maintains basally-located homogenous nuclei without atypia *** PanIN-1B: Development of papillary architecture *** PanIN-2: nuclear atypia *** PanIN-3: Prominent nuclear abnormalities with complete loss of polarity and marked cytologic atypia (carcinoma-in-situ) ** Low-grade PanIN is present in >50% of 50yo *
Summary:
Please note that all contributions to Surgopaedia may be edited, altered, or removed by other contributors. If you do not want your writing to be edited mercilessly, then do not submit it here.
You are also promising us that you wrote this yourself, or copied it from a public domain or similar free resource (see
Surgopaedia:Copyrights
for details).
Do not submit copyrighted work without permission!
Cancel
Editing help
(opens in new window)
Search
Search
Editing
Pancreatic cancer
(section)
Add topic
