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=== '''Embryology''' === ** Three separate excretory organs appear in development, which succeed each other in time and space, such that only the last is retained *** Pronephros **** Present only as clusters of cells at the cranial part of the urogenital ridge **** Only the duct persists, which becomes known as the mesonephric (Wolffian) duct, which opens caudally into the cloaca *** Mesonephros **** A ridge becomes visible, the mesonephric ridge or mesonephros **** Mesonephric tubules, the first tubules, develop individually here and open into the mesonephric duct **** Some of these ducts develop into genital structures such as epididymis *** Metanephros (the true precursor of the kidney) **** Forms caudal to the mesonephros as a mass of new tubules **** This mass induces a bud, the ureter, to grow from the caudal end of the mesonephric duct **** Ureteric bud then separates from the mesonephric duct, leaving it to form part of the bladder and ductus deferens **** Metanephros continues to develop in the pelvis and is supplied by internal iliac artery. It gradually migrates cranially, acquiring new blood supply from aorta. **** At first, the hilum is anterior, but the kidney rotates 90 degrees medially
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