Editing Pancreatic cancer (section)

== '''Risk factors''' ==

* Genetic
** PRSS1 (familial pancreatitis) - 40% lifetime risk
** SPINK1 (familial pancreatitis) - 50x risk
** STK11 (Peutz-Jeghers) - 100x lifetime risk
** CDKN2A (familial atypical mole and melanoma syndrome) - >40x lifetime risk
** CFTR (CF) - thick secretions lead to chronic pancreatitis and 30x lifetime risk
** BRCA2 - 10x risk
** MLH1 (Lynch) - 8x risk
** APC (FAP) - 4x risk
** Familial pancreatic cancer - two or more first-degree relatives with PDAC that do not fulfil the criteria for other genetic conditions - 18x increased risk, especially if diagnosed <50yo
* Environmental
** Smoking - 1-3x RR - linear association
** Obesity
** Diabetes - especially, new-onset diabetes in elderly patients with weight loss or abdominal pain - can be caused by PDAC - should be imaged