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== '''Pathophysiology''' == * Cortisol is produced in zona fasciculata and released in a diurnal rhythm * Crosses cell membranes and has effects on gene transcription in nucleus * Key impacts on gluconeogenesis, glycogenolysis, immune response, peripheral uptake of glucose, sodium transport, and other processes * Hypercortisolism: ** Electrolyte disturbances ** Proteolysis ** Lipolysis ** Inhibition of peripheral uptake of glucose ** Reduction of bone formation ** Inhibited muscle formation ** Impaired collagen formation and wound healing
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