Editing Haemolytic anaemia (section)

== Presentation ==

* Acute haemolysis
** Rapid fall in Hb concentration with increased reticulocyte count (at least 4-5%) in the absence of blood loss
** The elevated reticulocyte count can't be explained by accelerated RBC production due to recent bleeding, repletion of iron, vitamin B12, folate or copper, or administration of EPO
** Combination of increased LDH and reduced haptoglobin is 90% specific
** Normal LDH and haptoglobin is >25mg/dL is 92% sensitive
* Chronic haemolysis
** Stable Hb, high reticulocyte count, normal LDH, normal bilirubin

{| class="wikitable"
|'''Finding'''
|'''Change in hemolytic anemia'''
|-
|Anemia*
|Decreased hemoglobin

Decreased hematocrit
|-
|Bone marrow response/recovery
|Increased reticulocyte count

Underestimation of HbA1C
|-
|Release of RBC contents
|Increased LDH

Increased indirect bilirubin

Decreased haptoglobin

Hemoglobinemia in intravascular hemolysis¶

Hemoglobinuria in intravascular hemolysis¶
|-
|RBC morphology changesΔ
|Spherocytes or microspherocytes in immune hemolysis

Schistocytes in microangiopathic hemolysis

Blister or bite cells in oxidant injury

Sickle cells in sickle cell disease

Target cells and teardrop cells in thalassemia
|}