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== '''Refractory GORD:''' == * Note that recurrence of reflux symptoms and/or reflux oesophagitis on PPIs is closely related to status of LOS and oesophageal motility. If both are abnormal, 80% recurrence. If both are normal, 8% recurrence. ** ?medication timing and adherence ** ?Differences in PPI metabolism ** ?Residual acid reflux ** ?Non-acid reflux ** ?Reflux hypersensitivity ** ?Functional heartburn ***
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