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Colon cancer
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=== '''Morphological variants''' === *** Mucinous (11-17%) **** Tumours producing extracellular mucin, which may aid in tissue plane dissection and penetration **** Defined as >50% mucin within the tumour mass *** Signet ring (1-2%) **** >50% of tumour mass made up of cells with intracellular mucin pushing nucleus to the side **** Strong association with HNPCC **** Worse prognosis and much higher rate of stage III or IV disease at diagnosis **** *** Medullary **** Associated with dMMR tumours, via HNPCC or BRAF **** Good prognosis *** Micropapillary *** Serrated *** Cribriform *** Comedo *** Adenosquamous (0.2%) **** Worse prognosis *** Spindle cell *** Undifferentiated ** Synoptic report *** Clinical information **** Perforation? **** Obstruction? **** Location **** Pre-op radiotherapy **** Residual cancer post-surgery **** Involvement of adjacent organs **** New primary or recurrence *** Macroscopic **** Tissue banking **** Specimen images **** Specimen length **** Tumour site **** Anterior peritoneal reflection **** Perforation? **** Intactness of mesorectum **** Maximum tumour diameter **** Peritoneum **** Distance from margins - proximal, distal, circumferential **** Lymph nodes **** Polyps **** Comments **** Nature and site of blocks *** Microscopic **** Tumour type **** Histological grade **** Depth of invasion **** Small vessel invasion **** Intramural vein invasion **** Extramural vein invasion **** Perineural invasion **** Margins - proximal, distal, circumferential **** Lymph node involvement **** Isolated extramural deposits **** Apical node involvement **** Distant metastases **** Coexisting abnormalities **** Response to treatment **** Comment *** Ancillary studies **** IHC for MMR genes *** Synthesis **** Stage **** Stage group **** Residual tumour status
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