Editing Stomach (section)

=== Other secretion products ===

** Intrinsic factor
*** Produced by parietal cells
*** Essential for absorption of       B12 in the TI
*** Secreted in great surplus
*** Not inhibited by PPIs
*** Intrinsic factor deficiency       can develop in patients with pernicious anaemia or those undergoing       total gastrectomy - need B12 supplementation either orally or by       injection
** Pepsin
*** Proteolytic enzyme
*** Secreted by the glands of       the gastroduodenal mucosa
** Mucus and bicarbonate
*** Secreted by surface mucous       cells and mucous neck cells
*** Neutralise gastric acid at       the mucosal surface
*** Production is stimulated by       vagus, cholinergic agonists, prostaglandins, and some bacterial toxins
*** Inhibited by       anticholinergic drugs and NSAIDs
*** Helicobacter pylori breaks       down mucin