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=== UC === {| class="wikitable" |'''Characteristic''' |'''Ulcerative colitis''' |'''Crohn disease''' |- |Disease distribution | ** Colon and rectum | ** Commonly affects terminal ileum ** May involve any part of the gastrointestinal tract (ie, mouth to rectum) |- |Skip lesions (ie, spatially intermittent bowel inflammation) | ** Rare | ** Common |- |Vascularity of the mucosa | ** Friable mucosa with loss of vascularity | ** Normal vasculature adjacent to inflamed mucosa |- |Ulceration | ** Mainly mucosal ** Transmural only in severe colitis | ** Aphthous ulcers: Small discrete mucosal ulcers ** Transmural ulcers: Deeper ulcers that involve the colon wall |- |Cobblestone appearance | ** Not seen | ** Common |- |Stricture | ** Rare | ** Common |- |Fistula | ** Rare | ** Common ** Examples include perianal, enterocutanous, or rectovaginal fistula |- |Perianal disease | ** Rare | ** Common ** Examples include perianal fistula or deep anal fissure |}
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