Editing Breast cancer genetics (section)

== Indications for genetic testing (based on eviQ Australian guidelines) ==

* Manchester Score can be used to evaluate who gets government funding through PBS - need a score >10, but can also use eviQ criteria
* Known breast/ovarian cancer genetic susceptibility in the family
* Triple negative diagnosed <60yo
* Individual characteristics:
** Male breast cancer
** Breast cancer and Jewish ancestry
** Two primary breast cancers in the same person, where the first occurred at <60yo
** Breast cancer and another associated cancer in the same person at any age (pancreatic, ovarian, prostate)
** Breast cancer diagnosed <=40yo
** Lobular breast cancer AND diffuse-type gastric cancer (in the same person or in the same family)
** Breast cancer diagnosed <50yo with limited family structure or knowledge
** Breast cancer and a personal or family history suggestive of:
*** PJS
*** PTEN hamartoma syndrome
*** Li-Fraumeni
*** NF1
* Family characteristics
** Two first or second-degree relatives with breast or ovarian cancer on the same side of the family, AND:
*** Additional relatives
*** Breast cancer diagnosed <50yo
*** >1 primary breast cancer in the same person
*** Breast and ovarian cancer in the same person
*** Jewish ancestry
*** Male breast cancer
*** Pancreatic cancer
*** High-grade (Gleason 7) or metastatic prostate cancer


iPrevent familial risk assessment tool is the recommended way to assess familial risk in Australia
[[Category:Breast]]