Editing Peptic ulcer disease (section)

=== '''Uncomplicated     PUD (also needed for all other situations below):''' ===

** H . Pylori eradication
*** HP7 - see separate topic
** Avoid NSAIDs/steroids
*** Will need 8 weeks of PPI,       and consider maintenance PPI if need to stay on NSAIDs long-term
** Stop smoking
** Restrict EtOH to one per day
** Antacids
*** See description under       'GORD' topic
*** Mostly replaced by       antisecretory therapy in modern times, but can be used for symptom       control
** Sucralfate
*** See 'GORD' topic
*** Not clearly established to       benefit PUD
** Histamine antagonists
*** See 'GORD'
*** Despite differences in       potency, RCTs have demonstrated that all H2-receptor antagonists result       in healing rates of 70-80% after 4 weeks and 80-90% after 8 weeks
** PPIs
*** See 'GORD'
*** Most potent anti-secretory       agent
*** Healing rate 85% at 4 weeks       and 96% at 8 weeks