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Sepsis/SIRS
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== '''Definition''' == * Sepsis is defined as '''life-threatening organ dysfunction''' caused by a dysregulated host response to infection ** SEPSIS 3 (2016) defines '''organ dysfunction''' as an acute change in total SOFA score of two or more points consequent to infection ** This was found to have superior predictive value than SIRS score alone (only 0.74 vs 0.64 though, so SIRS score does retain some validity) * Septic shock - a subset of sepsis in which underlying circulatory and cellular/metabolic abnormalities are profound enough to substantially increase mortality
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