Editing Pancytopaenia (section)

== Aetiology ==
{| class="wikitable"
|'''Acquired'''
|-
|
** Bone marrow infiltration/replacement
*** Malignant
**** Acute leukemias
**** Chronic leukemias/myeloproliferative neoplasms (MPN)
**** Myelodysplastic syndromes (MDS)
**** Multiple myeloma
**** Metastatic cancer
*** Non-malignant
**** Myelofibrosis
**** Infectious (eg, fungal, tuberculous)
**** Storage diseases
*** Bone marrow failure
**** Immune destruction/suppression
***** Aplastic anemia/paroxysmal nocturnal hemoglobinuria
***** Medications¶
****** Cytotoxic drugs
****** Idiosyncratic reactions to medications
***** Large granular lymphocyte leukemia
***** Autoimmune disorders (eg, systemic lupus erythematosus [SLE], rheumatoid arthritis [RA], sarcoidosis)
***** Hemophagocytic lymphohistiocytosis (HLH)
**** Nutritional
***** Megaloblastic (vitamin B12, folate)
***** Excessive alcohol
***** Other (eg, copper deficiency, zinc toxicity)
***** Malnutrition/anorexia nervosa with gelatinous degeneration
**** Marrow suppression
***** Viral infection (eg, HIV, hepatitis, Epstein-Barr virus [EBV])
**** Ineffective hematopoiesis (eg, MDS, nutritional)
** Destruction/sequestration/redistribution
*** Consumption
**** Disseminated intravascular coagulation (eg, associated with sepsis, acute promyelocytic leukemia) 
*** Splenomegaly
**** Portal hypertension/cirrhosis
**** Infections (eg, EBV)
**** Autoimmune disorders (eg, SLE, RA/Felty syndrome)
**** Malignancies (eg, lymphomas, MPN)
**** Myelofibrosis with myeloid metaplasia
**** Storage diseases (eg, Gaucher)
|-
|'''Congenital'''
|-
|
** Wiskott Aldrich syndrome
** Fanconi anemia
** Dyskeratosis congenital/telomere biology disorders
** Shwachman-Diamond syndrome
** GATA2 deficiency
** Hemophagocytic lymphohistiocytosis (HLH)
|}