Editing Pancreas (section)

== '''Embryology''' ==

* Dorsal and ventral pancreatic     buds form separately from evaginations of the endodermal epithelium of the     duodenum, at the junction of foregut and midgut, in 4th week
** Pluripotent pancreatic      epithelial stem cells give rise to both exocrine (acinar) and endocrine      (islet) cell lines, and the ductal network
** First organised islets      appear around 10 weeks
* Ventral bud rotates from     ventral mesogastrium to dorsal mesogastrium
* These buds fuse around day 40
** Dorsal bud -> anterior      part of head of pancreas, pancreatic body and tail (Dorsal = Dominant)
** Ventral bud -> posterior      part of head of pancreas, uncinate process
* Both ventral and dorsal buds     develop their own primitive ductal system, and both systems contribute to     the mature pancreatic ductal system
** Proximal aspect of the      dorsal anlage duct forms the duct of Santorini (accessory duct)
** Distal aspect of dorsal duct      combines with the duct of the ventral bud to form the duct of Wirsung
** Duct of Wirsung is      eventually the major drainage pathway, and enters the duodenum through      the major papilla on medial wall of D2, at major duodenal papilla
* Pancreas divisum = failure of     dorsal and ventral ducts to fuse (see separate topic)