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Liver
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== '''Embryology''' == * Common progenitor cell with biliary tree and pancreas * Liver primordium begins to form in week 3, as an outgrowth of endodermal epithelium at the distal end of the foregut - 'hepatic diverticulum' or 'liver bud' ** The connection between the hepatic diverticulum and foregut persists, albeit narrowed, as the bile duct * Hepatic cells develop cords and intermingle with the vitelline and umbilical veins to form hepatic sinusoids * Mesoderm ofΒ the septum transversum connects the liver to the ventral abdominal wall and foregut, and eventually form the falciform ligament and lesser omentum * Some mesoderm differentiates into visceral peritoneum on the surface of the liver * In the fetal circulation, the vitelline veins carry blood from the yolk sac to the sinus venosus and ultimately form a network of veins around the foregut that drain into the developing hepatic sinusoids. These vitelline veins eventually fuse to form the PV, SMV and splenic veins. The sinus venosus eventually becomes the hepatic veins and retrohepatic IVC. The paired umbilical veins carry oxygenated blood to the fetus, initially draining into the sinus venosus, but from week 5 onwards, they begin to drain into the hepatic sinusoids. The right umbilical vein ultimately disappears, and the left umbilical vein later drains via the ductus venosus into the hepatocardiac channel, which will later become the retrohepatic IVC. * Bile is first formed in week 12, and can enter the GIT *
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