Editing Leukaemia (section)

== '''Chronic lymphocytic leukaemia (CLL)''' ==

* Epidemiology
** Most common leukaemia in the western world
** Slight male predominance
** Mainly after the age of 50 years
* Pathophysiology
** Disease of B lymphocytes
** Progressive accumulation of relatively morphologically normal, mature but functionally incompetent lymphocytes
* Staging
** Use Rai system with Binet modification - correlates with survival
**

{| class="wikitable"
|'''Risk (Binet staging)'''
|'''Stage'''
|'''Description'''
|-
|Low
|0
|Lymphocytosis in blood or bone marrow
|-
|Intermediate
|I
|Lymphocytosis + enlarged lymph nodes
|-
|
|II
|Lymphocytosis + enlarged liver or spleen with or without lymphadenopathy
|-
|High
|III
|Lymphocytosis + anemia (Hgb <11 g/dL) with or without enlarged liver, spleen, or lymph nodes
|-
|
|IV
|Lymphocytosis + thrombocytopenia (platelet count <100,000/microL) with or without anemia or enlarged liver, spleen, or lymph nodes
|}

* Treatment
** Reserved for fit patients with advanced-stage disease