Editing Antibiotics (section)

== Empiric antibiotics for abdominal infections (from eTG 15/5/25) ==

* Surgical triple antibiotics
** Amoxicillin 1g QID
** Metronidazole 500mg BD
** Gentamicin 4-5mg/kg daily
* If aminoglycosides are contraindicated, use piperacillin/tazobactam 4.5g QID
* Non-severe hypersensitivity reaction to penicillin: ceftriaxone 2g daily/metronidazole 500mg BD
* Severe immediate or severe delayed (days after) reaction to penicillin: (for immediate hypersensitivity, also appropriate to give ceftriaxone/metronidazole in hospitalised patients if it is felt to be a better regimen than the below; however in delayed hypersensitivity must avoid cephalosporins)
** Gentamicin
** Clindamycin 600mg TDS
** Consider adding metronidazole if gram-negative anaerobes are expected
* Oral step-down therapy: Augmentin DF or Bactrim DS/metronidazole